About Us
Contact Us
Login to Protein Lounge!

MIF Regulation of Innate Immune Cells

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The innate immune response to bacteria is essential for survival but the systemic release of inflammatory mediators results in the life-threatening Septic-shock reaction. Macrophages are essential effector cells of innate immunity that play a pivotal role in the recognition and elimination of invasive microorganisms. Mediators released by activated macrophages orchestrate innate and adaptive immune host responses. The cytokine MIF (Macrophage Migration Inhibitory Factor) is an integral mediator of the innate immune system. Monocytes and macrophages constitutively express large amounts of MIF, which is rapidly released after exposure to bacterial toxins and cytokines. MIF exerts potent proinflammatory activities and is an important cytokine of septic shock. MIF regulates innate immune responses to endotoxin and gram-negative bacteria by modulating the expression of [...]


1.Macrophage defense mechanisms against intracellular bacteria.
Weiss G, Schaible UE.
Immunol Rev. 2015 Mar;264(1):182-203. doi: 10.1111/imr.12266. Review.
2.Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74.
Heinrichs D, Knauel M, Offermanns C, Berres ML, Nellen A, Leng L, Schmitz P, Bucala R, Trautwein C, Weber C, Bernhagen J, Wasmuth HE.
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17444-9. doi: 10.1073/pnas.1107023108. Epub 2011 Oct 3.
You can get all the details on this pathway through subscription