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MIF Regulation of Innate Immune Cells

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The innate immune response to bacteria is essential for survival but the systemic release of inflammatory mediators results in the life-threatening Septic-shock reaction. Macrophages are essential effector cells of innate immunity that play a pivotal role in the recognition and elimination of invasive microorganisms. Mediators released by activated macrophages orchestrate innate and adaptive immune host responses. The cytokine MIF (Macrophage Migration Inhibitory Factor) is an integral mediator of the innate immune system. Monocytes and macrophages constitutively express large amounts of MIF, which is rapidly released after exposure to bacterial toxins and cytokines. MIF exerts potent proinflammatory activities and is an important cytokine of septic shock. MIF regulates innate immune responses to endotoxin and gram-negative bacteria by modulating the expression of [...]


1.Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.
Calandra T, Froidevaux C, Martin C, Roger T.
J Infect Dis. 2003 Jun 15; 187 Suppl 2:S385-90.
2.MIF regulates innate immune responses through modulation of Toll-like receptor.
Roger, T. et al.
Nature. 2001 Dec 20-27; 414(6866):920-4.
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