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MODY (Maturity-Onset Diabetes of Young)

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Diabetes mellitus is a chronic disease characterized by high blood glucose levels that requires long-term medical attention both to limit the development of its devastating complications and to manage them when they do occur. The pancreatic Beta-cell and its secretory product insulin are central in the pathophysiology of diabetes. There are two main types of diabetes, Type-I, which is insulin dependent, and Type-II, which is non-insulin dependent. Type-II diabetes is a complex and heterogeneous disease caused by both environmental and genetic factors. It maybe of various forms each of which is characterized by variable degrees of insulin resistance and Beta-cell dysfunction, and which together lead to hyperglycemia. At each end of this spectrum are single gene disorders that affect the [...]


1.Insulin signaling in health and disease.
White MF
Science. 2003 Dec 5; 302(5651):1710-1.
2.Sulphonylurea action revisited: the post-cloning era.
Gribble FM, Reimann F
Diabetologia. 2003 Jul; 46(7):875-91. Epub 2003 Jun 18
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