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Mating-Pheromone Response Pathway in Budding Yeast

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Description

The MAPK (Mitogen-Activated Protein Kinase) cascades play a pivotal role in many aspects of cellular functions, and are evolutionarily conserved from yeast to mammals. In Saccharomyces. cerevisiae, there are five MAP kinase signal transduction pathways that regulate mating, filamentous growth, high osmolarity response, maintenance of cellular integrity, and ascospore formation. The best-defined yeast MAPK pathway in S. cerevisae is involved in the mating of haploid cells. Yeast may exist either as haploid or diploid cells. The haploid cells have two sexual phenotypes characterized by the expression of a set of genes involved in mating that are not expressed in diploids. The mating response to generate diploids is stimulated by the release of small peptide mating pheromones, Alpha-factor from Mat-Alpha cells [...]

References:

1.Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Widmann C, Gibson S, Jarpe MB, Johnson GL.
Physiol Rev. 1999 Jan;79(1):143-80.
2.Map kinases in fungal pathogens.
Xu JR.
Fungal Genet Biol. 2000 Dec;31(3):137-52.
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