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Description |
In organisms as diverse as fruit flies and mammals, circadian rhythms are
controlled by a transcriptional feedback system whose activity fluctuates as a
function of the light-dark cycle. In mammals, the master clock (circadian
pacemaker) resides in the SCN (Suprachiasmatic Nucleus) of the brain s
hypothalamus and this endogenous clock drives physiology and behavior. In the
absence of external time cues, the SCN master clock generates cycles of
approximately but not exactly 24 hours, and its phase must therefore be
readjusted every day. This task depends on the retina, which detects changes in
light intensity during the day s light-dark cycle (the photoperiod) and
transmits this information to the SCN neurons (Ref.1).
The mammalian
circadian feedback loop in gene expression is established by [...] |
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References:
1. Molecular bases for circadian clocksDunlap JCCell. 1999 Jan 22; 96(2): 271-90. Review. No abstract available2. Mop3 is an essential component of the master circadian pacemaker in mammalsBunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS, Bradfield CACell. 2000 Dec 22; 103(7): 1009-17
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