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Metabolic States and Circadian Oscillators

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In organisms as diverse as fruit flies and mammals, circadian rhythms are controlled by a transcriptional feedback system whose activity fluctuates as a function of the light-dark cycle. In mammals, the master clock (circadian pacemaker) resides in the SCN (Suprachiasmatic Nucleus) of the brain s hypothalamus and this endogenous clock drives physiology and behavior. In the absence of external time cues, the SCN master clock generates cycles of approximately but not exactly 24 hours, and its phase must therefore be readjusted every day. This task depends on the retina, which detects changes in light intensity during the day s light-dark cycle (the photoperiod) and transmits this information to the SCN neurons (Ref.1).

The mammalian circadian feedback loop in gene expression is established by [...]


1.Molecular bases for circadian clocks
Dunlap JC
Cell. 1999 Jan 22; 96(2): 271-90. Review. No abstract available
2.Mop3 is an essential component of the master circadian pacemaker in mammals
Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS, Bradfield CA
Cell. 2000 Dec 22; 103(7): 1009-17
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