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Mismatch Repair in Prokaryotes

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The integrity of genetic information depends on the fidelity of DNA replication and on the efficiency of several different DNA repair processes. Among many types of DNA repair, the general MMR (DNA Mismatch Repair) pathway is responsible for correcting base substitution mismatches which is generated during DNA replication in organisms from bacteria to mammals. The MMR system improves the fidelity of DNA synthesis by 100-1000 fold. The MMR also corrects IDLs (Insertion-Deletion Loops) which may occur during replication and recombination of DNA. MMR also able to correct DNA damages caused by internal or external sources. Inactivation or deterioration of this pathway has been linked to a variety of cancers, most notably Hereditary Non-Polyposis Colorectal Cancer. MMR can be permanent or [...]


1.Excision repair invades the territory of mismatch repair.
Sancar A.
Nat Genet. 1999 Mar; 21(3):247-9.
2.DNA mismatch repair.
Kunkel TA, Erie DA.
Annu Rev Biochem. 2005;74:681-710
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