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Mitochondrial Apoptosis

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Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and function of an organism. In this process, cells that are no longer needed or that will be detrimental to an organism or tissue are disposed of in a neat and orderly manner; this prevents the development of an inflammatory response, which is often associated with Necrotic cell death. There are at least two broad pathways that lead to Apoptosis, an "Extrinsic" and an "Intrinsic" Pathway. In both pathways, signaling results in the activation of a family of Cys (Cysteine) Proteases, named Caspases that act in a proteolytic cascade [...]


1.Teaching resources. Apoptosis.
Wilk S.
Sci STKE. 2005 May 24;2005(285):tr16.
2.Apoptosome formation and caspase activation: is it different in the heart?
Czerski L, Nunez G.
J Mol Cell Cardiol. 2004 Sep;37(3):643-52. Review.
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