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Mitotic Roles of Polo Like Kinases

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Description

Cell division is characterized by orchestrated events of chromosome segregation, distribution of cellular organelles, and the eventual partitioning and separation of the two daughter cells. Mitosis is a highly regulated process that assures the proper allotment of genetic material between each pair of daughter cells. It proceeds through successive stages of well-defined and coordinated sub-processes. Entry into mitosis is regulated by the CDC2 (Cell Division Cycle-2)/Cyclin-B heterodimer. CDC2/Cyclin-B activity drives the events of early mitosis, such as nuclear breakdown, chromosome condensation and spindle formation by phosphorylating cellular substrates. While CDC2 (the catalytic subunit of the heterodimer) is required to drive the events of early mitosis, protein kinases structurally distinct from CDKs (Cyclin-Dependent Kinases) also make important contributions to cell cycle progression. The PLKs (Polo-Like [...]

References:

1.The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.

Qian YW, Erikson E, Taieb FE, Maller JL.

Mol Biol Cell. 2001 Jun; 12(6): 1791-9.

2.The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae.

Lee KS, Song S, Erikson RL.

Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25): 14360-5.

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