ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

NF-KappaB (p50-p65) Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Survival of an organism is dependent on its ability to rapidly and effectively respond to adverse changes in its environment. Eukaryotic cells possess a number of distinct signal transduction pathways that couple environmental stimuli to specific changes of gene expression. One such pathway is the transcription factor NF-KappaB (Nuclear Factor-KappaB), which is implicated in the regulation of many genes that code for mediators of apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammatory responses (Ref.1). NF-KappaB is composed of homo- and heterodimeric complexes of members of the Rel (NF-KappaB) family: p50, p65 (RelA), c-Rel, p52 and RelB. The most common and best-characterized form of NF-KappaB is the p65/p50 heterodimer. Each dimer combination exhibits differences in DNA binding affinity and transactivation potential. The activation of NF-KappaB is thought to be part of a [...]

References:

1.The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr.
Annu Rev Immunol. 1996;14:649-83.
2.Two pathways to NF-KappaB.
Joel L. Pomerantz and David Baltimore.
Molecular Cell, Vol. 10, 693-701, October 2002June 2002, Volume 16, Number 6, Pages 1053-1068.
You can get all the details on this pathway through subscription