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NF-KappaB Activation by EBV

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The EBV (Epstein–Barr Virus) is a member of the human herpes virus family, which infects greater than 90% of the world’s population. EBV is linked to the development of several malignancies, primarily of lymphoid and epithelial cell origin, including Burkitt’s lymphoma, post-transplant lymphoma, AIDS-associated lymphomas, Hodgkin’s disease, T-Cell lymphoma, NPC (Nasopharyngeal Carcinoma), parotid gland carcinoma, and gastric carcinoma. EBV-encoded RNAs (EBERs) are the most abundant viral transcripts in latently EBV-infected cells (Ref.1).

EBV primarily targets B-lymphocytes with the potential to produce indefinitely proliferating lymphocytes. Although primary infection is controlled principally by an antiviral T-Cell response, EBV persists by establishing a latent infection in memory B-lymphocytes. The viral oncoprotein LMP1 (Latent Membrane Protein-1) is essential for EBV-mediated lymphocyte transformation. LMP1 is [...]


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