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NF-KappaB Orthologue in Fruitfly (Drosophila melanogaster)

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Description

NF-KappaB (Nuclear factor-KappaB)/Rel proteins are dimeric, sequence-specific transcription factors involved in the activation of an exceptionally large number of genes in response to inflammation, viral and bacterial infections, and other stressful situations requiring rapid reprogramming of gene expression. Rel/NF-KappaB transcription factors include a collection of proteins, conserved from the fruit fly Drosophila melanogaster to humans. Among the commonly used model organisms, these transcription factors are notably absent in yeast and the nematode Caenorhabditis elegans; in part, this may be because one of the primary roles of these factors is to control a variety of physiological aspects of immune and inflammatory responses. A pathway similar to the Rel/NF-KappaB signaling pathway may also control certain defense responses in plants (Ref.1).

In Drosophila, three [...]

References:

1.The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus.
Rothwarf DM, Karin M.
Sci STKE. 1999 Oct 26;1999(5):RE1.
2.Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling.
Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelievre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ.
Nat Immunol. 2003 Aug;4(8):794-800. Epub 2003 Jul 20.
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