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NFAT Signaling and Lymphocyte Interactions

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The optimum functioning of the immune system is crucial for human survival. The invading pathogens are encountered by the cells of the immune system, which include T-Cells, B-Cells, macrophages, neutrophils, basophils, eosinophils, endothelial cells, or mast cells. These cells have distinct roles in the immune system, and cell-to-cell communication among these cells is an indispensable prerequisite for the stimulation of the optimum immune response. In the process, cytokines serve as signal molecules for communication that are induced by several cell-signaling cascades. NFATs (Nuclear factors of activated T-Cells), a family of transcription factors expressed by diverse cell types of the immune system plays a pivotal role in the process. Originally described in T-Cells, NFATs have now been implicated in the activation [...]


1.Role of transcription factor NFAT in the immune response.
Kuklina EM, Shirshev SV.
Biochemistry (Mosc). 2001 May; 66(5): 467-75. Review
2.NFAT signaling: choreographing the social lives of cells.
Crabtree GR, Olson EN.
Cell. 2002 Apr; 109 Suppl: S67-79. Review.
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