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NFAT in Immune Response

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Antigenic stimulation of lymphocytes and other cells of the immune system initiates a complex series of intracellular signal transduction pathways that lead to the expression of a panel of immunoregulatory genes, whose function is critical to the initiation and coordination of the immune response. NFATs (Nuclear Factors of Activated T-Cells), a family of transcription factors expressed both inside and outside of diverse cell types of the immune system, play a pivotal role in the process. Originally described in T-Cells, NFATs have now been implicated in the activation of mast cells, B-Cells, NK (Natural Killer) cells, monocytes, and play a key role in the expression of a number of immunologically important genes, including a wide array of cytokines: IL-2, IL-3, IL-4, [...]


1.NFAT proteins: key regulators of T-cell development and function.
Macian F.
Nat Rev Immunol. 2005 Jun;5(6):472-84. Review.
2.Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.
Im SH, Rao A.
Mol Cells. 2004 Aug 31;18(1):1-9. Review.
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