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NTHi-INDUCED SIGNALING

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Description

The Gram-negative bacterium NTHi (Nontypeable Haemophilus influenzae) is an important human respiratory pathogen in children and adults. In children, it causes OM (Otitis Media), the most common childhood infection and the leading cause of conductive hearing loss (Ref.1) whereas in adults, it exacerbates COPD (Chronic Obstructive Pulmonary Diseases), the fourth leading cause of death in the United States. A hallmark of both OM and COPD is mucus overproduction that mainly results from up-regulation of mucin, a primary innate defensive response for mammalian airways (Ref.2).

The molecular mechanisms underlying the pathogenesis of NTHi-induced infections involve activation of NF-kappaB (Nuclear Factor-kappa B), a transcriptional activator of multiple host defense genes involved in immune and inflammatory responses. NTHi strongly activates NF-kappaB in human epithelial [...]

References:

1.Molecular determinants of the pathogenesis of disease due to non-typable Haemophilus influenzae
Rao VK, Krasan GP, Hendrixson DR, Dawid S, St Geme JW 3rd
FEMS Microbiol Rev. 1999 Apr; 23(2): 99-129. Review
2.Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Lemjabbar H, Basbaum C
Nat Med. 2002 Jan;8(1): 41-6
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