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NgR-75(NTR)-Mediated Signaling

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Axon regeneration is arrested in the injured CNS (Central Nervous System) by axon growth-inhibitory ligands expressed in oligodendrocytes/myelin and reactive astrocytes in the lesion and by fibroblasts in scar tissue. Growth cone receptors bind inhibitory ligands, activating a Rho-family GTPase intracellular signaling pathway that disrupts the actin cytoskeleton inducing growth cone collapse/repulsion. The known inhibitory ligands include Eph (Ephrins) expressed on astrocyte/fibroblast membranes; the myelin/oligodendrocyte-derived growth inhibitors Nogo, MAG (Myelin-Associated Glycoprotein), and OMGP (Oligodendrocyte Myelin Glycoprotein); and membrane-bound Sema (Semaphorins) produced by meningeal fibroblasts invading the scar (Ref.1).

The ligand-binding receptor for all the myelin inhibitors is NgR (Nogo Receptor) and requires p75(NTR) (p75 Neurotrophin Receptor) for transmembrane signaling. NgR is a GPI (Glycosyl Phosphatidylinositol)-linked LRR (Leucine-Rich Repeat) protein expressed in [...]


1.Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function.
Vourc'h P, Andres C.
Brain Res Brain Res Rev. 2004 May; 45(2):115-24. Review.
2.Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions.
Mingorance A, Fontana X, Sole M, Burgaya F, Urena JM, Teng FY, Tang BL, Hunt D, Anderson PN, Bethea JR, Schwab ME, Soriano E, del Rio JA.
Mol Cell Neurosci. 2004 May; 26(1):34-49.
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