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Notch Signaling

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Description

The Notch signaling pathway is a fundamental signaling system used by neighboring cells to communicate with each other in order to assume their proper developmental role. Notch proteins are cell surface transmembrane-spanning receptors which mediate critically important cellular functions through direct cell-cell contact. Interaction between Notch and its proposed ligands initiates a signaling cascade that governs cell fate decisions such as differentiation, proliferation, and apoptosis in numerous tissue types. The core elements of the Notch signaling system include the Notch receptor, DSL ligands (Delta and Serrate/Jagged in Drosophila and vertebrates, Lag2 in Caenorhabditis elegans) and CSL DNA-binding proteins (CBF1/RBPJ-kappa in vertebrates, Su(H) [Suppressor of hairless] in Drosophila, Lag1 in C. elegans). Four paralogs of the Notch gene, Notch1, 2, 3 [...]

References:

1.Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.
Ohishi K, Varnum-Finney B, Flowers D, Anasetti C, Myerson D, Bernstein ID.
Blood. 2000 May 1; 95(9): 2847-54.
2.Neoplastic transformation by Notch requires nuclear localization.
Jeffries S, Capobianco AJ.
Mol Cell Biol. 2000 Jun; 20(11): 3928-41.
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