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Notch Signaling

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The Notch signaling pathway is a fundamental signaling system used by neighboring cells to communicate with each other in order to assume their proper developmental role. Notch proteins are cell surface transmembrane-spanning receptors which mediate critically important cellular functions through direct cell-cell contact. Interaction between Notch and its proposed ligands initiates a signaling cascade that governs cell fate decisions such as differentiation, proliferation, and apoptosis in numerous tissue types. The core elements of the Notch signaling system include the Notch receptor, DSL ligands (Delta and Serrate/Jagged in Drosophila and vertebrates, Lag2 in Caenorhabditis elegans) and CSL DNA-binding proteins (CBF1/RBPJ-kappa in vertebrates, Su(H) [Suppressor of hairless] in Drosophila, Lag1 in C. elegans). Four paralogs of the Notch gene, Notch1, 2, 3 [...]


1.Notch signaling as a novel regulator of metabolism.
Bi P, Kuang S.
Trends Endocrinol Metab. 2015 May;26(5):248-55. doi: 10.1016/j.tem.2015.02.006. Epub 2015 Mar 21. Review
2.Signaling in colon cancer stem cells.
Roy S, Majumdar AP.
J Mol Signal. 2012 Aug 6;7(1):11. doi: 10.1186/1750-2187-7-11.
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