ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Notch Signaling

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The Notch signaling pathway is a fundamental signaling system used by neighboring cells to communicate with each other in order to assume their proper developmental role. Notch proteins are cell surface transmembrane-spanning receptors which mediate critically important cellular functions through direct cell-cell contact. Interaction between Notch and its proposed ligands initiates a signaling cascade that governs cell fate decisions such as differentiation, proliferation, and apoptosis in numerous tissue types. The core elements of the Notch signaling system include the Notch receptor, DSL ligands (Delta and Serrate/Jagged in Drosophila and vertebrates, Lag2 in Caenorhabditis elegans) and CSL DNA-binding proteins (CBF1/RBPJ-kappa in vertebrates, Su(H) [Suppressor of hairless] in Drosophila, Lag1 in C. elegans). Four paralogs of the Notch gene, Notch1, 2, 3 [...]

References:

1.Notch signaling as a novel regulator of metabolism.
Bi P, Kuang S.
Trends Endocrinol Metab. 2015 May;26(5):248-55. doi: 10.1016/j.tem.2015.02.006. Epub 2015 Mar 21. Review
2.Signaling in colon cancer stem cells.
Roy S, Majumdar AP.
J Mol Signal. 2012 Aug 6;7(1):11. doi: 10.1186/1750-2187-7-11.
You can get all the details on this pathway through subscription