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Nur77 Signaling in T-Cell

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Description

During development in the thymus, immature thymocytes which express self-reactive TCR (T-Cell Receptor) are eliminated from the developing T-cell repertoire. This process of clonal deletion, or negative selection is mediated by Apoptotic signals delivered to thymocytes whose TCR have a high affinity for Self-Antigen/MHC (Major Histocompatibility Complexes)-Antigen Complexes. This mechanism is crucial for generating a peripheral T-lymphocyte population which will recognize only foreign pathogens and helps prevent unwanted immune responses which could lead to autoimmunity (Ref.1). Negative selection therefore represents a first line of defense in a battle for immunological tolerance of self. Thus, TCR-mediated thymocyte negative selection in the form of Apoptosis is important for elimination of self-reactive T-Cells. Among the proteins that are induced by TCR signaling is [...]

References:

1.Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
Rajpal A, Cho YA, Yelent B, Koza-Taylor PH, Li D, Chen E, Whang M, Kang C, Turi TG, Winoto A.
EMBO J. 2003 Dec 15;22(24):6526-36
2.Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.
Youn HD, Liu JO.
Immunity. 2000 Jul;13(1):85-94.
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