During development in the thymus, immature thymocytes which express self-reactive TCR (T-Cell Receptor) are eliminated from the developing T-cell repertoire. This process of clonal deletion, or negative selection is mediated by Apoptotic signals delivered to thymocytes whose TCR have a high affinity for Self-Antigen/MHC (Major Histocompatibility Complexes)-Antigen Complexes. This mechanism is crucial for generating a peripheral T-lymphocyte population which will recognize only foreign pathogens and helps prevent unwanted immune responses which could lead to autoimmunity (Ref.1). Negative selection therefore represents a first line of defense in a battle for immunological tolerance of self. Thus, TCR-mediated thymocyte negative selection in the form of Apoptosis is important for elimination of self-reactive T-Cells. Among the proteins that are induced by TCR signaling is [...]