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Oct4 in Mammalian ESC Pluripotency

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Stem cells are undifferentiated cells capable of producing virtually all cell types in our body. They are characterized by the ability to Self-renew and maintain Pluripotency. For proper developmental outcome, ESCs (Embryonic Stem Cells) must tightly regulate their differentiation status. Hundreds of genes have been identified, including several transcription factors, which have expression patterns tightly correlated with ESC differentiation. Very low number of transcription factors is responsible for regulating the development of an entire organism. These transcription factors form multiprotein complexes on DNA, thereby orchestrating the correct temporal–spatial expression of developmental genes. The process leads to the establishment of functional partnerships, with the combination rather than the individual activity of each factor eliciting specific transcriptional outcomes. Two key transcription factors, Oct4 (Octamer Binding Transcription [...]


1.The human OCT-4 isoforms differ in their ability to confer self-renewal.
Lee J, Kim HK, Rho JY, Han YM, Kim J.
J Biol Chem. 2006 Nov 3;281(44):33554-65.
2.Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct4 expression: the role of the cAMP/PKA pathway.
Faherty S, Fitzgerald A, Keohan M, Quinlan LR
In Vitro Cell Dev Biol Anim. 2007 Jan;43(1):37-47.
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