This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
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Description |
Most fatty acids have even number of carbon atoms and are therefore completely
converted to Acetyl-CoA. Some plants and marine organisms, however, synthesize
fatty acids with an odd number of carbon atoms. The final round of
Beta-Oxidation of these fatty acids forms Propionyl-CoA, which is converted to
Succinyl-CoA for entry into the Citric Acid Cycle. Propionyl-CoA can be derived
from breakdown of certain amino acids (Isoleucine, Valine and Methionine), but
in mammalian cells these pathways exist in mitochondria. Bacteria in the
ruminant animal digestive system provide a source of propionate which eventually
gets incorporated as odd-numbered fatty acids in milk fats, and this is the
major source for human metabolism.
The conversion of Propionyl-CoA to
Succinyl-CoA involves three enzymes. In the [...] |
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References:
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