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Oxidation of Polyunsaturated Fatty Acid

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Unsaturated fatty acids are Beta-oxidized in the normal pathway as far as possible. However, polyunsaturation or unsaturation at odd positions produces a molecule that the major pathways cannot utilize as a substrate. To solve this problem, a number of enzymes exist in the peroxisome to convert these molecules to appropriate substrates which can be shuttled into the normal pathway. Peroxisomes are capable of oxidizing a variety of substrates including polyunsaturated Enoyl-CoA esters. The Beta-Oxidation of unsaturated Enoyl-CoA esters in peroxisomes, and also in mitochondria, is not just chain-shortening but also involves the metabolizing of pre-existing carbon-to-carbon double bonds. In addition to the enzymes of the Beta-Oxidation spiral itself, this metabolism requires the participation of auxiliary enzymes: Delta-3, Delta2-Enoyl-CoA Isomerase; 2, [...]


1.Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae.
Gurvitz A, Hamilton B, Ruis H, Hartig A.
J Biol Chem. 2001 Jan 12; 276(2):895-903.
2.Peroxisomal beta-oxidation and polyunsaturated fatty acids.
Hiltunen JK, Filppula SA, Koivuranta KT, Siivari K, Qin YM, Hayrinen HM.
Ann N Y Acad Sci. 1996 Dec 27; 804:116-28. Review.
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