This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
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Description |
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Unsaturated fatty acids are Beta-oxidized in the normal pathway as far as possible. However, polyunsaturation or unsaturation at odd positions produces a molecule that the major pathways cannot utilize as a substrate. To solve this problem, a number of enzymes exist in the peroxisome to convert these molecules to appropriate substrates which can be shuttled into the normal pathway. Peroxisomes are capable of oxidizing a variety of substrates including polyunsaturated Enoyl-CoA esters. The Beta-Oxidation of unsaturated Enoyl-CoA esters in peroxisomes, and also in mitochondria, is not just chain-shortening but also involves the metabolizing of pre-existing carbon-to-carbon double bonds. In addition to the enzymes of the Beta-Oxidation spiral itself, this metabolism requires the participation of auxiliary enzymes: Delta-3, Delta2-Enoyl-CoA Isomerase; 2, [...] |
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References:
1. Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae.Gurvitz A, Hamilton B, Ruis H, Hartig A.J Biol Chem. 2001 Jan 12; 276(2):895-903.2. Peroxisomal beta-oxidation and polyunsaturated fatty acids.Hiltunen JK, Filppula SA, Koivuranta KT, Siivari K, Qin YM, Hayrinen HM.Ann N Y Acad Sci. 1996 Dec 27; 804:116-28. Review.
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