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P2Y Receptor Signaling

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Angiogenesis plays an important role in pathological events such as tumor growth, wound healing, psoriasis, and the ischemic retinopathies that occur in diabetes and sickle cell disease. The main modulators of the angiogenesis process in adults, is achieved through signaling by peptide growth factors, however, recent researches also emphasize the contribution of purines and pyrimidines to this process. Synergistic actions of purines and pyrimidines with growth factors aid in promoting cell proliferation (Ref.1). ATP (Adenosine Triphosphate), ADP (Adenosine Diphosphate), UTP (Uridine Triphosphate), UDP (Uridine Diphosphate) and adenosine play pivotal signaling roles in these long-term events, referred to as purinergic signaling, mediated via P1 and P2 receptors. Extracellular nucleotides exert their physiological effects through fast, ionotropic P2X, containing seven distinct receptors [...]


1.Involvement of P2Y receptors in the differentiation of haematopoietic cells.
Sak K, Boeynaems JM, Everaus H.
J Leukoc Biol. 2003 Apr; 73(4): 442-7. Review.
2.Cytokines induce upregulation of vascular P2Y (2) receptors and increased mitogenic responses to UTP and ATP.
Hou M, Moller S, Edvinsson L, Erlinge D.
Arterioscler Thromb Vasc Biol. 2000 Sep; 20(9): 2064-9.
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