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PDGF Pathway

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Directed cell migration is a critical feature of several physiological and pathological processes, including development, wound healing, atherosclerosis, immunity, angiogenesis, and metastasis. The migratory response involves actin cytoskeleton reorganization, polarization, cell adhesion and detachment. Thus, migration requires cell communication with adjacent cells and with ECM (Extracellular Matrix Components) and is triggered by a gradient of chemotactic factors, including PDGF (Platelet-Derived Growth Factor) and its receptors (Ref.1). PDGF is a member of a large family of growth factors, which includes VEGF (Vascular Endothelial Growth Factor), PlGF (Placental Growth Factor), and CTGF (Connective Tissue Growth Factor), a PDGF-like factor secreted by human vascular endothelial cells and fibroblasts. PDGFR (PDGF Receptors) are not uniformly distributed in the cell membrane, but rather concentrated in [...]


1.Role of the PI3K regulatory subunit in the control of actin organization and cell migration.
Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez-A C, Avila J, Carrera AC.
J Cell Biol. 2000 Oct 16; 151(2): 249-62.
2.Growth-promoting effect of platelet-derived growth factor on rat cardiac myocytes.
Liu J, Wu LL, Li L, Zhang L, Song ZE.
Regul Pept. 2005 Apr 15;127(1-3):11-8.
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