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PEDF Induced Signaling

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Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor growth and many vascular diseases. Endogenous angiogenesis inhibitors, particularly those that act broadly at the earliest stages, are excellent pharmacological tools in combating pathogenic vessel growth. PEDF (Pigment Epithelium Derived Factor) is a potent and broadly acting neurotrophic factor that promotes survival of neurons in many regions of the CNS (Central Nervous System) from degeneration caused by serum withdrawal or glutamate cytotoxicity and oxidative damage (Ref.1). Glutamate neurotoxicity involves an increase in intracellular calcium resulting from the opening of NMDA (N-Methyl D-Aspartate) channels.

PEDF is synthesized and secreted by RPE (Retinal [...]


1.Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor.
Tombran-Tink J, Barnstable CJ
Trends Mol Med. 2003 Jun; 9(6):244-50.
2.NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons.
Yabe T, Wilson D, Schwartz JP.
J Biol Chem. 2001 Nov 16; 276(46):43313-9. Epub 2001 Sep 11.
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