Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor growth and many vascular diseases. Endogenous angiogenesis inhibitors, particularly those that act broadly at the earliest stages, are excellent pharmacological tools in combating pathogenic vessel growth. PEDF (Pigment Epithelium Derived Factor) is a potent and broadly acting neurotrophic factor that promotes survival of neurons in many regions of the CNS (Central Nervous System) from degeneration caused by serum withdrawal or glutamate cytotoxicity and oxidative damage (Ref.1). Glutamate neurotoxicity involves an increase in intracellular calcium resulting from the opening of NMDA (N-Methyl D-Aspartate) channels.
PEDF is synthesized and secreted by RPE (Retinal [...]