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PGC1Alpha Pathway

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PGC1Alpha (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha) is a tissue-specific transcriptional coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for cellular energy metabolism and overall energy homeostasis (Ref.1). It is a key regulator of cardiac mitochondrial functional capacity and participates in the transduction of physiologic stimuli to energy production in the heart. The expression of the PGC1Alpha gene is upregulated after birth in the heart, before the known increase in mitochondrial biogenesis and switch from glucose to fatty acids as the chief energy substrate. PGC-1Alpha gene expression is activated by short-term fasting, a condition known to increase cardiac mitochondrial FAO (Fatty Acid Oxidation) rates. Moreover, cardiac-specific overexpression of PGC-1Alpha is sufficient to induce mitochondrial biogenesis [...]


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