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PI3K Signaling

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The (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation of cellular activities such as proliferation, differentiation, chemotaxis, survival, trafficking and Glucose homeostasis. On the basis of structural similarities, the members are sub-divided into three classes; Class I, II and III. The Class I and II PI3Ks are found only in metazoa, whereas, Class III PI3Ks are also found in unicellular eukaryotes. The Class I PI3Ks are sub-divided into two groups-the Class IA and Class IB PI3Ks. Class IA PI3Ks are heterodimeric enzymes consisting of regulatory subunits (p85-Alpha, p85-Beta or p55-Gamma) and a catalytic subunit (p110-Alpha, or p110-Delta). There is only one catalytic subunit and one [...]


1.Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD.
Annu. Rev. Cell. Dev. Biol. 2001;17:615-75.
2.Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.
Wymann MP, Marone R.
Curr. Opin. Cell Biol. 2005 Apr;17(2):141-9.
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