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PI3K Signaling in B-Lymphocyte

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PI3Ks (Phosphoinositide-3-Kinases) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired PI3K signaling leads to immunodeficiency, whereas unrestrained PI3K signaling contributes to autoimmunity and Leukemia. The Class I and III PI3Ks basically facilitate B-cell development through defined stages, resulting in at least three distinct lineages of mature B-lymphocytes. In B-cells, PI3K is activated within seconds of antigen-receptor triggering. The BCR (B-Cell antigen Receptor) plays a critical role in recognition of antigens and activation of B-cells. The BCR or mIg (Membrane Immunoglobulin) is associated with Ig-Alpha/CD79A (CD79A Antigen) and Ig-Beta/CD79B (CD79B Antigen) heterodimer. The mIg subunits bind antigen and cause receptor aggregation, while the Ig-Alpha/Ig-Beta subunits transduce signals to the cell interior [...]


1.Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation.
Al-Alwan MM, Okkenhaug K, Vanhaesebroeck B, Hayflick JS, Marshall AJ.
J Immunol. 2007 Feb 15;178(4):2328-35.
2.The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
Beer-Hammer S, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, N├╝rnberg B, Piekorz RP.
J Leukoc Biol. 2010 Jun;87(6):1083-95. Epub 2010 Mar 3.
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