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PI3K Signaling in Caenorhabditis elegans

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PI3Ks (Phosphoinositide 3-Kinases) are an important type of lipid kinase that form a large evolutionarily conserved family of enzymes that specifically phosphorylate inositol phospholipids at the D-3 position of the inositol ring. The C. elegans (Caenorhabditis elegans) PI3K is required for functional membrane trafficking machinery (Ref.1). C. elegans PI3K adaptor subunit aap-1 (Phosphoinositide 3-Kinase age-1 Adapter Subunit-58.5 KD) shares moderate sequence similarity with the p50/p55 adaptor subunits of their vertebrate and Drosophila counterparts. C. elegans PI3K also contains age-1 (Ageing Alteration-age-1), a homolog of vertebrate p110 catalytic subunits of PI3K (Ref.2 & 3).

An insulin receptor-like signaling pathway regulates C. elegans metabolism, development and longevity. The C. elegans daf-2 (Abnormal Dauer Formation-daf-2-207.1 KD/Insulin Receptor Homolog/Regulator of Lifespan and Dauer Formation) [...]


1.Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane.
Roggo L, Bernard V, Kovacs AL, Rose AM, Savoy F, Zetka M, Wymann MP, Muller F.
EMBO J. 2002 Apr 2; 21(7): 1673-83.
2.Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G.
J. Biol. Chem. 2002 Dec 20; 277(51): 49591-7.
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