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PKC-Theta Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


An effective immune response depends on the ability of specialized immunocytes to identify foreign molecules and respond by differentiation into mature effector cells. A cell-surface antigen recognition apparatus and a complex intracellular receptor-coupled signal-transducing machinery mediate this tightly regulated process, which operate at high fidelity to discriminate self from nonself antigens. Activation of T-Cell requires sustained physical interaction of the TCR (T-Cell Receptor) with a MHC (Major Histocompatibility Complex)–presented peptide antigen that results in a temporal and spatial reorganization of multiple cellular elements at the T-Cell–Antigen Presenting Cell contact region, a specialized region referred to as the IS (Immunological Synapse) or Supramolecular Activation Cluster. Recent studies have identified PKC-Theta (Protein Kinase-C-Theta), a member of the Ca2+-independent PKC family, as an essential component [...]


1.Protein kinase Ctheta: a new essential superstar on the T-cell stage.
Altman A, Isakov N, Baier G.
Immunol Today. 2000 Nov; 21(11): 567-73. Review.
2.Protein kinase C-theta (PKCtheta): it's all about location, location, location.
Altman A, Villalba M.
Immunol Rev. 2003 Apr; 192:53-63.
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