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PTEN Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Tumorigenesis is the result of abnormal activation of growth programs in the cells. Cancer cells escape normal growth control mechanisms as a consequence of activating mutations, or increased expression of one or more cellular protooncogenes, and/or inactivating mutations, or decreased expression of one or more tumor suppressor genes. Most oncogene and tumor suppressor gene products are components of signal transduction pathways that control cell cycle entry or exit, promote differentiation, sense DNA damage and initiate repair mechanisms, or regulate cell death programs. PTEN (Phosphatase and Tensin Homologue Deleted from Chromosome-10)/MMAC1 (Mutated in Multiple Advanced Cancers-1)/TEP1 (TGF-Beta Regulated and Epithelial Cell Enriched Phosphatase-1) has recently been identified as one of the most frequently mutated tumor suppressors in human cancer that functions [...]


1.Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.
Cully M, You H, Levine AJ, Mak TW.
Nat Rev Cancer. 2006 Feb 2
2.The complexity of PTEN: mutation, marker and potential target for therapeutic intervention.
Steelman LS, Bertrand FE, McCubrey JA.
Expert Opin Ther Targets. 2004 Dec;8(6):537-50. Review.
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