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Parkinson’s Disease Pathway

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Description

Parkinson s disease is a Neurodegenerative disorder characterized by the progressive loss of Dopaminergic neurons in the substantia nigra and the appearance of intracellular inclusions, named Lewy bodies and Lewy neurites in the remaining nigral neurons. The Substantia nigra is located in the midbrain region of the brain. It consists of two parts: the SNc (pars compacta), and the SNr (pars reticulata). The pars compacta produces dopamine and is the part that degenerates in Parkinson s disease. It is the second most common form of neurodegenerative disease after Alzheimer s, affecting about 1% of people over 65 years old and 4-5% of people over 85 years. Symptoms of Parkinson s disease include a resting tremor, rigidity, bradykinesia, gait dysfunction and postural instability. It is [...]

References:

1.The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration
Hattori N.
Rinsho Shinkeigaku. 2004 Nov;44(11):821-3.
2.The biochemistry of Parkinson's disease.
Cookson MR.
Annu Rev Biochem. 2005;74:29-52. Review.
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