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Pathogenesis of Gliomas

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Tumors of the Central Nervous System (CNS) are devastating as they are difficult to treat and may cause grave disability or death. CNS Gliomas pose particularly difficult problems because of their tendency toward malignancy, rate of tumor spread, and the lack of effective therapy. Gliomas are the most common intracranial malignant tumors in humans (Ref.1). In vertebrates, the embryonic neural tube (neuroectoderm) gives rise to the main cell types of the CNS, including neurons, astrocytes, oligodendrocytes and ependymal cells. The neural crest derives from the dorsal lip of the neural tube, and its cells migrate extensively during embryonic development, giving rise to various tissues, including the Peripheral Nervous System (PNS). In both the CNS and PNS, the appearance of neurons [...]


1.Molecular biology of glioma tumorigenesis.
Ware ML, Berger MS, Binder DK.
Histol. Histopathol. 2003 Jan;18(1):207-16.
2.The molecular and genetic basis of neurological tumours.
Zhu Y, Parada LF.
Nat. Rev. Cancer. 2002 Aug;2(8):616-26.
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