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Pathogenesis of Helicobacter pylori Infection

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The gastrointestinal tract represents an important barrier between human hosts and microbial populations. One potential consequence of host-microbial interactions is the development of mucosal inflammation. A paradigm for such chronic host-microbial relationships is carriage of Helicobacter pylori, Gram-negative bacteria that colonize the stomachs of humans and primates. H. pylori colonization induces chronic gastritis in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric adenocarcinoma, and gastric mucosal lymphoproliferative disease. However, only a small percentage of persons carrying H. pylori develop clinical sequelae; enhanced risk may be related to differences in expression of specific bacterial products, to variations in the host inflammatory response to the bacteria, or to specific interactions between host and microbe (Ref.1).

The [...]


1.Helicobacter pylori: an emerging infectious disease.
McManus TJ.
Nurse Pract. 2000 Aug; 25(8):40, 43-4, 47-8 passim; quiz 54-5.
2.Helicobacter pylori virulence and genetic geography.
Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R
Science. 1999 May 21; 284(5418):1328-33. Review.
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