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Pathogenesis of Multiple Sclerosis

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MS (Multiple Sclerosis) is an inflammatory and demyelinating disease of the CNS (Central Nervous System). MS is classified according to its clinical course into several categories: benign, RR (Relapsing-Remitting, the most common variant), PR (Progressive-Relapsing), PP (Primary-Progressive) and SP (Secondary-Progressive). MS first manifests itself as a series of attacks followed by complete or partial remissions as symptoms mysteriously lessen, only to return later after a period of stability. Rarely, patients may have a PR course in which the disease takes a progressive path punctuated by acute attacks. PP, SP, and PR are sometimes lumped together and called Chronic Progressive MS (Ref.1). Initial and subsequent symptoms may dramatically vary in their expression and severity over the course of the disease that [...]


1.Multiple sclerosis.
Compston A, Coles A.
Lancet. 2002 Apr 6; 359(9313): 1221-31. Review. Erratum in: Lancet 2002 Aug24; 360(9333): 648.
2.The epidemiology of multiple sclerosis: principles, achievements, and recommendations.
Compston A.
Ann Neurol. 1994 Dec; 36 Suppl 2:S211-7.
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