Signals that derive from cell adhesion to the ECM (Extracellular Matrix) regulate important physiological events including cell motility and growth, and most often involve changes in the organization of the actin cytoskeleton. Cells interact with the ECM via transmembrane receptors, termed integrins, located at the cell surface. Binding of integrins to the ECM is accompanied by a localized clustering of these receptors, with the subsequent recruitment of structural and signaling molecules to the sites of matrix attachment, focal contacts, providing links to the actin cytoskeleton (Ref.1). Numerous proteins present at the cytoplasmic face of FA (Focal Adhesions) include cytoskeletal proteins such as vinculin and talin. In addition, numerous "signaling" proteins with enzymatic activity (e.g., kinases and GTPases) are also components [...]