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Phosphatidylcholine Biosynthesis Pathway
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Phosphatidylcholine (once given the trivial name lecithin ) is usually the most abundant phospholipid in animal and plants, often amounting to almost 50% of the total, and as such it is the key building block of membrane bilayers. In particular, it makes up a very high proportion of the outer leaflet of the plasma membrane. Phosphatidylcholine is also the principal phospholipid circulating in plasma, where it is an integral component of the lipoproteins, especially the HDL (High Density Lipoprotein). It is a neutral or zwitterionic phospholipid over a pH range from strongly acid to strongly alkaline (Ref.1).
There are two mechanisms for the biosynthesis of phosphatidylcholine. Choline itself is not synthesized by animal cells, but is obtained from dietary sources or by [...]
Phosphatidylcholine biosynthesis inside the nucleus: is it involved in regulating cell proliferation?
Hunt AN, Postle AD.
Adv Enzyme Regul. 2004; 44:173-86.
Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues. A critical role for phosphatidic acid.
Holic R, Zagorsek M, Griac P.
Eur J Biochem. 2004 Nov; 271(22):4401-8.
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