ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Phosphatidylcholine Biosynthesis in S. cerevisiae

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

PC (Phosphatidylcholine) is the most abundant Phospholipid in the yeast S. cerevisiae (Saccharomyces cerevisiae) and the major Phospholipid present in eucaryotic cell membranes. It serves as a major structural component of cellular membranes and as a source of several lipid messengers. There are two pathways for PC synthesis in yeast, the CDP-Choline (Cytidine Diphosphate-Choline) pathway (a part of Kennedy Pathway) and the CDP-DAG (Cytidine Diphosphate-Diacylglycerol). Both pathways function to synthesize PC in wild-type cells (Ref.1). The CDP-DAG pathway is used primarily by cells in the absence of exogenous Choline. The PC synthesized by this pathway is constantly metabolized to free Choline and PA (Phosphatidate/Phosphatidic Acid) via the reaction catalyzed by PLD1 (Phospholipase-D1). The free Choline is then incorporated back into [...]

References:

You can get all the details on this pathway through subscription