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Phospholipase-C Pathway

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Inositol lipid-specific PLC (Phospholipase-C) isozymes are key signaling proteins in the cellular action of many hormones, neurotransmitters, growth factors, and other extracellular stimuli. PLC are soluble proteins that are partly cytosolic and partly associated with membrane. The PLC family in human is comprised of 13 subtypes. On the basis of their structure, they have been divided into six classes, PLC-Beta (Beta 1, 2, 3 and 4), PLC-Gamma (Gamma 1 and 2), PLC-Delta (Delta 1, 3 and 4), PLC-Epsilon, PLC-Zeta and PLC-Eta (Eta1 and 2) types. The molecular weights of each are 85kDa for the Delta form, 120-155kDa for both the Beta and Gamma forms, and 230-260kDa for the Epsilon form. These groups also differ in the mechanisms by which the [...]


1.Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
Horowitz LF, Hirdes W, Suh BC, Hilgemann DW, Mackie K, Hille B.
J Gen Physiol. 2005 Sep;126(3):243-62.
2.PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands.
Dotson CD, Roper SD, Spector AC.
Chem Senses. 2005 Sep;30(7):593-600. Epub 2005 Aug 31.
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