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Phospholipid Biosynthesis in E. coli

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Biological membranes are composed of hundreds of distinct proteins and phospholipids. Phospholipids are diacylglycerol derivatives with a hydrophilic, zwitter ionic, often charged headgroup at position C3 of the glycerol backbone. The properties of phospholipids give lipid bilayer membranes their self-organizing structure. Phospholipids are usually composed of two fatty acid chains esterified to two of the carbons of glycerol phosphate, the phosphate being esterified to a hydroxyl group of another hydrophilic compound, such as choline, ethanolamine or serine.

In general, E. coli and most related gram-negative bacteria do not contain phosphatidylcholine, phosphatidylinositol, sphingolipids, glycolipids, plasmalogens, or sterols, which are characteristic of eucaryotic systems. Phosphatidylethanolamine is the predominant phospholipid of E.coli along with PG (Phosphatidylglycerol) and Cardiolipin. All phospholipids contain sn-Glycerol-3-Phosphate esterified with fatty acids [...]


1.Pathways for phosphatidylcholine biosynthesis in bacteria.
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
Microbiology. 2003 Dec; 149(Pt 12):3461-71.
2.Biosynthesis of phosphatidylcholine in bacteria.
Sohlenkamp C, Lopez-Lara IM, Geiger O.
Prog Lipid Res. 2003 Mar; 42(2):115-62. Review.
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