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Presenilin-Mediated Signaling

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Presenilins are polytopic transmembrane proteins, mutations in which are associated with the occurrence of Early-onset familial Alzheimer s disease, a rare form of the disease that results from a single-gene mutation. The physiological functions of Presenilins are unknown, but they may be related to Developmental signaling, Apoptotic signal transduction, or processing of selected proteins, such as the Beta-APP (Beta-Amyloid precursor protein). Presenilin homologues identified in species that do not have an Alzhemier s disease suggests that they may have functions unrelated to the disease, homologues having been identified in Mouse, Drosophila melanogaster, Caenorhabditis elegans and other members of the eukarya including Plants. In humans, there are two known Presenilins, PS1 (Presenilin-1) and PS2 (Presenilin-2). PS1 and PS2 proteins are composed of 467 and 448 amino acids, respectively, and are 67% [...]


1.Neuropsychological function in nondemented carriers of presenilin-1 mutations.
Ringman JM, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Fairbanks L, Paz F, Varpetian A, Maldonado HC, Macias-Islas MA, Murrell J, Ghetti B, Kawas C.
Neurology. 2005 Aug 23;65(4):552-8.
2.Presenilin-interacting proteins.
Chen Q, Schubert D.
Expert Rev Mol Med. 2002 Aug 22;2002:1-18.
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