ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Progesterone-Induced Oocyte Maturation in X. laevis

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Female fertility requires precise regulation of oocyte meiosis. Females from nearly every species of animal are born with their full complement of oocytes; however, these immature oocytes remain arrested in Prophase-I of meiosis, till the time of ovulation (Ref.1). During this long period of Prophase arrest, the oocyte becomes enclosed into a follicle, and the follicle-enclosed oocyte grows, accumulates molecular reserves and acquires its competence in an orderly manner for completion of meiotic divisions, fertilization and early embryonic development. The Prophase block is released when oocyte growth is completed (i.e., at the time of ovulation) (Ref.2). Just before ovulation, Gonadotropins stimulate ovarian follicular development, which in turn promotes oocytes to mature, by reentering the meiotic cycle. Oocyte maturation is defined [...]

References:

1.The Xenopus cell cycle: an overview.
Philpott A, Yew PR.
Methods Mol Biol. 2005;296:95-112.
2.Signal transduction. Fishing at the cell surface.
Maller JL.
Science. 2003 Apr 25;300(5619):594-5.
You can get all the details on this pathway through subscription