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Prolactin Signaling

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Prl (Prolactin), a multifunctional hormone secreted by the anterior pituitary gland and to a lesser extent by numerous extrapituitary tissues, affects more physiological processes than all other pituitary hormones combined. It was originally identified by its ability to stimulate the development of the mammary gland and lactation. However, this hormone has been established to be present in all vertebrates, and involved in more than 300 separate effects (Ref.1), which can be ascribed to six broad categories: (i) reproduction and lactation, (ii) growth and development, (iii) endocrinology and metabolism, (iv) brain and behaviour, (v) immunomodulation and (vi) osmoregulation (Ref.2). It acts as a pleiotropic cytokine promoting cellular proliferation and differentiation of a variety of cell types (Ref.3).

Prl activates a mitogenic [...]


1.Mammary gland development and the prolactin receptor.
Binart N, Ormandy CJ, Kelly PA.
Adv Exp Med Biol. 2000;480:85-92. Review.
2.Src family kinases are required for prolactin induction of cell proliferation.
Fresno Vara JA, Caceres MA, Silva A, Martin-Perez J.
Mol Biol Cell. 2001 Jul;12(7):2171-83.
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