Eukaryotic transcription is a highly regulated process, and acetylation plays
a major role in this regulation. Acetylation can occur on histones, DNA-binding
TF (Transcription Factors), acetylases, nuclear import factors, non-nuclear
proteins (Alpha-tubulin) and proteins that shuttle from the nucleus to the
cytoplasm, such as the Importin-Alpha family of nuclear import factors.
Acetylation can modify the recognition of DNA, the stability of proteins and the
interaction between proteins. They regulate different cellular processes, such
as microtubule function or nuclear import (Ref.1). By modifying chromatin
proteins and transcription-related factors, these acetylases regulate diverse
functions, including DNA recognition, protein-protein interaction, protein
stability, and transcription of many genes (Ref.2).
Acetylation complexes such as PCAF
(p300/CBP-Associated Factor), p300/CBP (CREB Binding Protein), TAFs
(TBP-Associated Factors), SRC1 [...]