Quantcast
ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Protein Acetylation and Deacetylation

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Eukaryotic transcription is a highly regulated process, and acetylation plays a major role in this regulation. Acetylation can occur on histones, DNA-binding TF (Transcription Factors), acetylases, nuclear import factors, non-nuclear proteins (Alpha-tubulin) and proteins that shuttle from the nucleus to the cytoplasm, such as the Importin-Alpha family of nuclear import factors. Acetylation can modify the recognition of DNA, the stability of proteins and the interaction between proteins. They regulate different cellular processes, such as microtubule function or nuclear import (Ref.1). By modifying chromatin proteins and transcription-related factors, these acetylases regulate diverse functions, including DNA recognition, protein-protein interaction, protein stability, and transcription of many genes (Ref.2).

Acetylation complexes such as PCAF (p300/CBP-Associated Factor), p300/CBP (CREB Binding Protein), TAFs (TBP-Associated Factors), SRC1 [...]

References:

1.Acetylation: a regulatory modification to rival phosphorylation?
Kouzarides T.
EMBO J. 2000 Mar 15; 19(6): 1176-9. Review.
2.Acetylation of histones and transcription-related factors.
Sterner DE, Berger SL.
Microbiol Mol Biol Rev. 2000 Jun; 64(2): 435-59.
You can get all the details on this pathway through subscription