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RANK Signaling in Osteoclasts

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TNF (Tumor Necrosis Factor) and TNFR (Tumor Necrosis Factor Receptor) family proteins play important roles in the control of cell death, proliferation, autoimmunity, the function of immune cells, or the organogenesis of lymphoid organs. Recently, novel members of this large family have been identified that have critical functions in immunity and that couple lymphoid cells with other organ systems such as bone remodeling and mammary gland formation in pregnancy. Bone remodeling results from the coordinate action of bone resorption by osteoclasts and the formation of new bone by osteoblasts. Regulation of bone remodeling occurs through multiple mechanisms that ultimately converge on the interaction of osteoclasts or their precursors with osteoblasts and bone marrow stromal cells. Osteoblasts and osteoclasts arise from [...]


1.Cellular and molecular mechanisms of bone remodeling.
Raggatt LJ, Partridge NC.
J Biol Chem. 2010 Aug 13;285(33):25103-8. Epub 2010 May 25.
2.The mechanism of osteoclast differentiation induced by IL-1.
Kim JH, Jin HM, Kim K, Song I, Youn BU, Matsuo K, Kim N.
J Immunol. 2009 Aug 1;183(3):1862-70. Epub 2009 Jul 8.
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