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RAR-Alpha-PML Fusion During APL

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AMLs (Acute Myeloid Leukemias) are characterized with chromosomal translocations resulting in the formation of fusion proteins. Understanding PML (Acute Promyelocytic Leukemia Inducer) function has become an area of intense research because of its involvement in the pathogenesis of APL (Acute Promyelocytic Leukemia), a distinct subtype of Myeloid Leukemia. In the vast majority of APL case studies, the PML gene (on Chromosome-15) fuses to the RAR-Alpha gene (Retinoic Acid Receptor-Alpha) (on Chromosome-17) as a consequence of reciprocal and balanced chromosomal translocations. In the t(15;17) chromosomal translocation, which is specific for APL, PML is found in a reciprocal translocation with the RAR-Alpha resulting in the formation of PML-RAR-Alpha and RAR-Alpha-PML fusion proteins (Ref.1). In a normal cell Vitamin-A (all-trans-Retinol) from dietary sources [...]


1.The role of PML in tumor suppression.
Salomoni P, Pandolfi PP.
Cell. 2002 Jan 25;108(2):165-70.
2.Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype.
Miano JM, Berk BC.
Circ. Res. 2000 Sep 1;87(5):355-62.
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