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Rac1 Pathway

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To achieve strong adhesion to their neighbors and sustain stress and tension, epithelial cells develop many different specialized adhesive structures. Breakdown of these structures occurs during tumor progression with the development of a fibroblastic morphology characteristic of metastatic cells. Adhesion receptors of the Cadherin family have been implicated in these cellular processes, which play an important role in the development and maintenance of the differentiated epithelial phenotype during organogenesis and adult life. Cadherin-mediated adhesion requires the activity of the cytosolic proteins of the Rho subfamily members, Rho, Rac and CDC42 (Cell Division Cycle-42). They belong to the Ras Superfamily of small GTPases, whose function is regulated depending on the type of guanine nucleotide bound. Mammals have three closely related Rac isoforms, Rac1, Rac2 and Rac3 (Ref.1).

Rac1 is [...]


1.Role of Rac1 in fibronectin-induced adhesion and motility of human corneal epithelial cells.
Kimura K, Kawamoto K, Teranishi S, Nishida T.
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4323-9.
2.Rac1 and Rac2 regulate macrophage morphology but are not essential for migration.
Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, Tybulewicz VL, Ridley AJ.
J Cell Sci. 2006 Jul 1;119(Pt 13):2749-57. Epub 2006 Jun 13.
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