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Rap1 Pathway

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Rap1 (Krev-1/smg p21), a small-molecular-weight GTP-binding protein that belongs to the Ras-like superfamily of GTPases, is involved in signal transduction cascades. It is highly homologous to Ras but it is down regulated by its own set of GAPs (GTPase-Activating Proteins). Rap1 is implicated in the regulation of a variety of cellular processes including the control of platelet activation, T-cell anergy, B-Cell activation, and neuronal differentiation. Very recently, Rap was shown to be involved in the control of cell adhesion, in particular the regulation of integrin activation by inside-out signaling. In humans, four isoforms of Rap, Rap1A, Rap1B, Rap2A, and Rap2B, exist. Rap1A and Rap1B share more than 90% sequence identity. Rap1A/B is the closest relative of the Ras protein with more than 50% sequence [...]


1.The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.
Seastone DJ, Zhang L, Buczynski G, Rebstein P, Weeks G, Spiegelman G, Cardelli J.
Mol Biol Cell. 1999 Feb;10(2):393-406.
2.Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.
Lee JH, Cho KS, Lee J, Kim D, Lee SB, Yoo J, Cha GH, Chung J.
Mol Cell Biol. 2002 Nov;22(21):7658-66.
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