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Regulation of eIF4 and p70S6K

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Description

eIF4 (Eukaryotic Initiation Factor-4) and p70S6K play critical roles in translational regulation. The signaling pathway that regulates p70S6k also regulates the phosphorylation of 4EBP1 (4E-Binding Protein), although there appears to be a bifurcation in the pathway upstream of p70S6K and 4EBP1. Recruitment of mRNAs to ribosomes to initiate translation is mediated by initiation factors of the eIF4 group and the PABP (Poly (A)-Binding Protein). The eIF4 group includes eIF4A (Eukaryotic Translation Initiation Factor-4A), an RNA helicase; eIF4B (Eukaryotic Translation Initiation Factor-4B), an RNA-binding protein that stimulates eIF4A; eIF4E (Eukaryotic Translation Initiation Factor-4E), a cap-binding protein; and eIF4-gamma (Eukaryotic Translation Initiation Factor-4-Gamma), the central organizing protein that colocalizes eIF4E, eIF4A, eIF3 (Eukaryotic Translation Initiation Factor-3), PABP, the eIF4E kinase MNK1 (MAPK-Interacting Kinase-1) and RNA in the 48S initiation complex. (Ref.1).

Several stimuli, including growth factors [...]

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