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Remodeling of Adherens Junctions

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The intercellular Adherens Junctions (AJs) are specialized sub-apical structures that function as principle mediators of cell-cell adhesion. Their disassembly correlates with a loss of cell-cell contact and an acquisition of migratory potential. The Adherens Junctions have a crucial role both as sensors of extracellular stimuli and in regulating the dynamics of epithelial cell sheets or with neighboring cells. Cadherins, the Type-I transmembrane proteins of the Adherens Junctions, are principally responsible for homotypic cell-cell adhesion. E-Cadherin, which is present primarily in epithelia, is the best-characterized Cadherin and represents the prototype of classical Cadherins. The extracellular domain of E-Cadherin binds to Ca2+ (Calcium) and forms complexes with the extracellular domains of E-Cadherin molecules on neighboring cells. The cytoplasmic domain of E-Cadherin associates [...]


1.Disassembling adherens junctions: breaking up is hard to do.
D'Souza-Schorey C.
Trends Cell Biol. 2005 Jan;15(1):19-26.
2.Protecting your tail: regulation of cadherin degradation by p120-catenin.
Kowalczyk AP, Reynolds AB.
Curr. Opin. Cell Biol. 2004 Oct;16(5):522-7.
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