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Renin-Angiotensin Pathway

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Description

Proliferation and migration of VSMCs (Vascular Smooth Muscle Cells) in arteries plays an important role in the pathophysiology of atherosclerosis, hypertension, and restenosis after angioplasty. A wide variety of growth factors, cytokines, and hormones activate these responses in blood vessels. A prominent growth factor for VSMCs is Angiotensin (Angiotensin-I and II), the main peptide of the Renin Angiotensin System. Renin, an enzyme acts upon a circulating substrate, angiotensinogen that undergoes proteolytic cleavage to form the decapeptide Angiotensin-I. Vascular endothelium, particularly in the lungs, has an enzyme, ACE (Angiotensin Converting Enzyme), that cleaves off two amino acids to form the octapeptide, Angiotensin-II. Multiple signal transduction pathways are involved in mediating Angiotensin receptor stimulation of cell proliferation, cell migration, and other responses. In addition, [...]

References:

1.Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells.
Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB.
J Pharmacol Exp Ther. 2002 Nov; 303(2): 563-73.
2.Angiotensin II and renal fibrosis.
Mezzano SA, Ruiz-Ortega M, Egido J.
Hypertension. 2001 Sep; 38(3 Pt 2): 635-8. Review.
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