About Us
Contact Us
Login to Protein Lounge!

Renin-Angiotensin Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Proliferation and migration of VSMCs (Vascular Smooth Muscle Cells) in arteries plays an important role in the pathophysiology of atherosclerosis, hypertension, and restenosis after angioplasty. A wide variety of growth factors, cytokines, and hormones activate these responses in blood vessels. A prominent growth factor for VSMCs is Angiotensin (Angiotensin-I and II), the main peptide of the Renin Angiotensin System. Renin, an enzyme acts upon a circulating substrate, angiotensinogen that undergoes proteolytic cleavage to form the decapeptide Angiotensin-I. Vascular endothelium, particularly in the lungs, has an enzyme, ACE (Angiotensin Converting Enzyme), that cleaves off two amino acids to form the octapeptide, Angiotensin-II. Multiple signal transduction pathways are involved in mediating Angiotensin receptor stimulation of cell proliferation, cell migration, and other responses. In addition, [...]


1.Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells.
Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB.
J Pharmacol Exp Ther. 2002 Nov; 303(2): 563-73.
2.Angiotensin II and renal fibrosis.
Mezzano SA, Ruiz-Ortega M, Egido J.
Hypertension. 2001 Sep; 38(3 Pt 2): 635-8. Review.
You can get all the details on this pathway through subscription