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Repair of 8-oxoG by hOGG1

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The genome of all living organisms are constantly exposed to exogenous and endogenous DNA-damaging agents and the greatest amount of damage is inflicted by the endogenous agents water and oxygen, which modify primarily the aromatic DNA bases. While ROS (Reactive Oxygen Species) such as hydroxyl radicals convert guanine (G) to 8-oxoguanine and thymine (T) to thymine glycol, water brings about the deamination of all bases carrying exocyclic amino groups (Ref.1).

Among the most deleterious of ROS-induced adducts is oxoG (7,8-dihydro-8-oxoguanine), which is formed by the oxidation of the guanine base in DNA. Guanine bases have a strong preference to pair with cytosine (C), but oxoG can pair both in Watson–Crick mode with cytosine and in Hoogsteen mode with adenine (A). [...]


1.A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site.
Sartori AA, Fitz-Gibbon S, Yang H, Miller JH, Jiricny J.
EMBO J. 2002 Jun 17; 21(12): 3182-91.
2.Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Bruner SD, Norman DP, Verdine GL.
Nature. 2000 Feb 24; 403(6772): 859-66.
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