ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Repair of Thymine Dimers in E. coli

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

UV radiation induces two of the most abundant mutagenic and cytotoxic DNA lesions such as CPD (Cyclobutane-Pyrimidine Dimers) or 6-4PPs (6-4 Pyrimidine Pyrimidone). The most common covalently linked adjoining pyrimidines are TT(Thymine dimers), T-C (Thymine-Cytosine dimers) and C-C (Cytosine-Cytosine dimers). T-T dimers cause kinks in the DNA strand that prevent both replication and transcription of that part of the DNA. Because they block DNA replication (and therefore prevent cells from reproducing), T-T dimers and other forms of UV damage cannot be inherited, and thus do not constitute mutations. Such kinds of DNA damage are known as premutational lesions because they prevent both transcription and replication of the genes in which they are present and these lesions are fatal if they go uncorrected [...]

References:

1.The role of Escherichia coli UvrB in nucleotide excision repair.
Seeley TW, Grossman L.
J Biol Chem. 1990 May 5; 265(13): 7158-65.
2.UV-induced DNA damage and repair: a review.
Sinha RP, Hader DP.
Photochem Photobiol Sci. 2002 Apr; 1(4): 225-36. Review.
You can get all the details on this pathway through subscription